Paloxi

PALOXI® snapshot DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) sense organ opponent with a healthy spine simile for this sensory receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical edict is C19H24N2O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the pursual geomorphologic formula: Palonosetron hydrochloride is a white to off -white gauze-like powder. It is freely soluble in water, soluble in propene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered solution for intravenous ® administration. all(prenominal) 5-ml vial of Paloxi injection contains 0.25 mg palonosetron bow as hydrochloride, 207.5 mg mannitol, edetate disodium dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

clinical PHARMACOLOGY Mechanism of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a juicy incidence of nausea and egest, particularly when current agents, such as cisplatin, ar used. 5-HT3 receptors are located on the kernel terminals of the vagus in the periphery and centrally in the chemoreceptor propel zone of the field of battle postrema. It is thought that chemotherapeutic agents name nausea and vomiting by releasing serotonin from the enterochromaffin cells of the miserable bowel and that the released s erotonin consequently activates 5-HT3 receptors located on pneumogastric afferents to founding father the vomiting reflex. Pharmacodynamics The effect of palonosetron on livestock pressure, heart rate, and electrocardiogram parameters including QTc...If you penury to get a encompassing essay, order it on our website: Ordercustompaper.com

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